In June, I took delivery of my 2021 F-450. It is nothing short of an amazing truck for safely towing heavy (over 18,000 lbs.) trailers. I tow at approximately 60 miles an hour and the ride is quiet and comfortable. Bumps are not an issue. When I drive unloaded and without a trailer on the same highways the ride is still quiet and comfortable with no jarring bumps. That's because the highways I travel on are in good shape. However when I travel on rough roads with pot holes I experience a very rough ride. So, I think the answer to your question is really this - what types of roads will you be travelling on as a daily driver. If the roads are in good shape - you will be fine. Bad roads equal a rough ride. As an aside, driving empty at 75 mph, I do not experience any unusual handling or vibration.