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P0351 and P0356 cylinder 1 and 6


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Recently I purchased a 2006 E250 with a 5.4L engine and about 153k miles. I’m aware I probably overpaid, but I didn’t mind since these vans have a reputation for being solid and long-lasting. There was no check engine light at the time, so I thought I got a good deal.

Unfortunately, about halfway home, the check engine light came on 🤣. I was pretty shocked—I guess I got played by the seller. Surprising, right?

The codes I’m dealing with are P0351 and P0356 (cylinders 1 and 6). So far, I’ve replaced the ECM, coils, and spark plugs, but the issue is still there. One thing I’ve noticed is that when I clear the codes, the van runs perfectly for about 3 minutes. After that, the codes return and it starts misfiring again. If I clear them, it runs fine briefly, then the cycle repeats.

Does anyone have any idea what might be causing this? I’ve seen suggestions like a bad alternator, faulty connectors, or a grounding issue. Any help would be greatly appreciated—thanks in advance.

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